Lo anterior establece la necesidad de realizar biopsia y un seguimiento cuidadoso de aquellos casos que presenten datos sugestivos de hiperplasia melanoctica y en los que se produzcan cambios en la evolucin clnica de alguna de las lesiones que pudiesen sugerir transformacin maligna
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Mislocalization and degradation of these proteins have been associated with a leakage of the endothelial barrier sufficient for the meningococcus to cross it via the paracellular route
S.LiS.-S.ChiuP.M.et al (2005)
Thus, we propose that the polar bond between Asn205 and the hydroxyl group of HQ indicates on an inhibitory effect on TyrBm
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