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Placebo-controlled, randomized trial of the addition of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide to titrated daily insulin glargine in patients with type 2 diabetes (AWARD-9)
When hypoglycemia is accompanied by a low concentration, or even absence, of ketone bodies in plasma and urine, hyperinsulinism and disorders of carnitine transport and mitochondrial fatty acid oxidation, including long-chain fatty acid oxidation disorders (lcFAODs), may be involved as cause
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Success requires integration with proper nutrition, regular exercise, and behavioral modifications
They reduce caspase-3 mRNA activity and enhance the expression of anti-apoptotic genes, including Bcl-2 and Bcl-xl [45, 46]
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