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In addition, activated B cells in RA patient peripheral blood drive inflammatory T helper cell activation and cytokine production via the ICOS-ICOSL pathway, while concomitantly upregulating T cell Glut1 expression to enhance glucose uptake (155)

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In contrast, if RBCs were loaded with human hexokinase, they showed a doubled glycolytic activity, a normal hexose monophosphate pathway, and normal ATP and 2,3-BPG concentrations ( Furthermore, as the 2,3-BPG concentration decreases and hemoglobin affinity for O 2 increases, there is also an accumulation of reactive species of oxygen (ROS) due to the impaired RBCs antioxidant capability (Yoshida et al., 2019)

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