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GLP-1 Microdose Program A low-dose compounded GLP-1 program designed for gradual weight management, metabolic support, and easier tolerance
L.ParkA.PattersonM.et al (2003)
The imbalance of gut microbiota will reduce the production of SCFAs, weaken the ability to activate SCFAs receptors, and affect GLP-1 secretion, resulting in abnormal glucose metabolism and lipid metabolism (Ma et al., 2019)
Data Animal Data Pregnant rats given subcutaneous doses of 0.3, 1, or 3 mg/kg exenatide extended-release every 3 days during organogenesis had systemic exposures 3-, 8-, and 19-times human exposure, respectively, at the MRHD of 2 mg/week BYDUREON BCISE based on plasma exenatide exposure (AUC) comparison
[21] Current labeling advises 5 mg kg day (or 150 mg m day) divided every 6-8 hours for pediatric patients beyond the neonatal period, with a single-dose maximum of 50 mg