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There are a couple of other scenarios in which acetaminophen is more likely to cause liver damage: Alcohol Use Disorder: Normally, alcohol is metabolized using the alcohol dehydrogenase enzymes, but in cases of chronic overconsumption or binge drinking, the CYP2E1 enzyme is upregulated to metabolize the extra alcohol

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Journal of epithelial biology and pharmacology , 5, 47-54

For example, BDNF has been implicated in craving and seeking-related behaviors in preclinical studies, with periods of cocaine abstinence that are characterized by high BDNF levels during craving episodes

doi: 10.1038/s41523-020-00212-6 76 TuomistoAEMakinenMJVayrynenJP