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Wnt ligands bind to Frizzled receptors on the cell surface, resulting in the increased stability of cytoplasmic -catenin, and its subsequent translocation into the nucleus, where it activates the transcription of MITF by interplay with lymphoid enhancer-binding factor 1 (LEF1)/T-cell factor (LEF1/TCF) (26)
Jones MD, Clifford BK, Stamatakis E, Gibbs MT
In addition, low testosterone levels can adversely affect male fertility [14]
Furthermore, AKT may directly activate the nicotinamide adenine nucleotide kinase (NADK) responsible for the phosphorylation of NADH forming NADPH (Koundouros and Poulogiannis, 2020)
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