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It has been proposed that COVID-19 infection could lead to the activation of normal mast cells by persistent viral particles or spike proteins, or to exaggeration of a preexisting but undiagnosed mast cell activation syndrome (159, 160)

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We defined two sets of genes, those either largely devoid of promoter bound NRF2 (Group I, green) or genes with high promoter bound NRF2 (Group II, purple) (Fig