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Until recently, the recommended strategy for intensifying insulin therapy was the addition of rapid-acting insulins (RAIs) to the treatment regimen, either as additional prandial injection or as part of a premixed insulin formula

It is mediated by reactive oxygen species (ROS) formed by the partial reduction of oxygen, including superoxide, hydrogen peroxide, and hydroxyl radical [273]

As a result, these agents may influence sympathetic and parasympathetic tone

***Consumer test, 85 subjects, 2x/day application