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Key Points The sculpting of neuronal connections during brain development depends on a precise balance between inhibition and excitation an excess of GABA (-aminobutyric acid)-mediated inhibition might prevent growth or synapse formation, whereas an excess of glutamatergic excitation could lead to toxicity

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After the formation of a ligand-receptor complex, it diffuses laterally in the plasma membrane until encountering a coated pit, where the receptor-ligand complex accumulates with clathrin, adaptor protein, and dynamin

ROS generation induced by HCV infection triggers anti-3-hydroxysterol 24-reductase (DHCR24) antibody production, suggesting that DHCR24 may be used as a prognostic biomarker for hepatitis C progression to hepatocellular carcinoma 56,97

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