Cheng Z, Cheng Y, Chen Q, Li M, Wang J, Liu H, Li M, Ning Y, Yu Z, Wang Y, et al
Activation of mTOR and upregulation of HIF-1 trigger enhanced glycolytic reprogramming in innate immune cells, which fulfills the elevated metabolic demands of trained immunity and synergizes with epigenetic remodeling to sustain the long-term pro-inflammatory and anti-pathogen memory phenotype of innate cells ( C
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