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These clinical results are consistent with our preclinical study of prediabetic mice fed an obesogenic diet in which linagliptin prevented arterial stiffening and vascular remodeling [42]

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In the SUSTAIN 6 trial, there was no difference in hospitalization for angina or heart failure between semaglutide and placebo [12], and this result was independent of baseline CV risk profile (Fig

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Overall, both medications maintain a similar safety profile, making them effective options with manageable side effects for most patients

Phenotypic heterogeneity is thought to be an evolutionarily selected bet-hedging strategy that cell populations benefit from via enhanced adaptability, resilience and survival chances in unpredictable or changing environments [1112]