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Commenters recommended that CMS use the lower of methodology to determine the eligibility cost threshold: Current methodology using the two times rule, OR The lowest GMC of significant procedures in the APC to which the code combination would be eligible for complexity adjustment

Fernandes, M

The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

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The semaglutide 2.4mg and the placebo group each had 201 participants

L.CasadoJ.Carrera-IzquierdoM.Sanchez-MartelesM.et al (2024)