Enforcement discretion ended April 22, 2025, for 503A pharmacies and May 22, 2025, for 503B outsourcing facilities
Published December 28, 2023
4.6.2 Retinal disease Diabetic retinopathy (DR) is the most prevalent microvascular complication of diabetes and the leading cause of preventable blindness among working-age individuals ( The secretion of VEGF and IL-6 is crucial in diabetic eye diseases ( A meta-analysis was done which indicates that albiglutide is linked to a higher risk of early-stage DR compared to placebo, while showing a reduced risk of late-stage DR compared to insulin ( 4.7 Pregnancy-related effects Although type 2 diabetes and obesity have been effectively treated with GLP-1 receptor agonists, their role in pregnancy and breastfeeding has been a controversial debate due to potential risks to the mothers health and fetal outcomes ( Since none of the GLP-1RA are approved in pregnancy, a cohort study approved the potency of liraglutide, in early pregnancy, despite its adverse outcomes such as preterm birth, preeclampsia and gestational diabetes mellitus (GDM) ( An observational cohort study involving 168 pregnant women exposed to GLP-1 receptor agonists during the first trimester found a 2.6% prevalence of major birth defects, comparable to 2.3% in the diabetic reference group
The only differences are in the amount of water added and the resulting concentration, since semaglutide doses are much smaller in milligrams
Phulrenu Chauhan, section head-endocrinology, PD Hinduja Hospital and MRC, says the moderation may reflect increasing adoption of tirzepatide following its introduction in the India market in March last year
Med., 7 (4), 232239
