It is important to note that some decrease in muscle mass can happen during the weight loss journey, whether someone is utilizing medications like GLP-1s or not
A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging
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(2009) 11:R71
In addition, although nonsignificant, findings from our pooled analysis suggest a trend favoring the use of GTR alone or STR with radiation therapy over STR alone
The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)
