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Preclinical studies have demonstrated no significant toxicity even at doses far exceeding therapeutic ranges

Sleep time was significantly lower in the methyl B12 group, who reported better sleep quality, focus, and a refreshed feel

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The crystal structure of this complex revealed important details about how F2PhEtyCbl interacts with CblC and glutathione, providing new insights into the enzyme's mechanism and the potential effects of antivitamins on B12 metabolism

Pharmaceutics, 17 (4), Article 470