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Rybelsus carries a boxed warning regarding the risk of thyroid C-cell tumors, based on rodent studies showing dose-dependent and treatment-duration-dependent increases in thyroid C-cell tumors

Medullary thyroid carcinoma is the rarest form of thyroid cancer, accounting for 3-4% of all cases, and is the specific type referenced in the warning

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Early phase 2 data showed average weight loss of approximately 24 percent at 48 weeks, with the STEP UP trial demonstrating 20.7 percent average weight reduction with the higher dose formulation at 72 weeks

Some women may find that fertility is affected by these medications, while others may notice improved hormonal balance because of weight loss