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While both are highly effective, they have key differences in how they work, their effectiveness, and their side effect profiles

27 Several, non-enzymatic cofactors like TAFs, mediators, and numerous enzymatic cofactors like the histone-modifying cofactors (histone deacetylase, histone acetyltransferase, histone methyltransferase, histone demethylase) and ATP-dependent chromatin-remodeling cofactors (SWI/SNF, ISWI, Mi-2/NuRD, and INO80/SWR1 families) have been discovered since

38 The capsaicin 8% patch can be used only in a physician's office and may increase pain in a minority of patients