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Despite the elevated heart rate, cardiovascular outcome trials have shown net cardiovascular benefits, suggesting that the modest chronotropic effect is outweighed by other protective mechanisms

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Proactive education, slow dose increases, lifestyle changes, and early use of supportive treatments can prevent symptoms from becoming severe

But here is what the headlines miss

The Lancet Diabetes & Endocrinology , 7(10), 932-944

Sip, Don't Chug This one is worth its own heading because it's a real source of nausea that's easy to avoid once you know about it