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Mice were given RSL3, a GSH peroxidase 4 (Gpx4) inhibitor, and found that Tregs were not able to survive minimal amounts of lipid peroxidation [36]

Various mediators, including inflammatory cytokines and prostaglandins, can affect paracellular TJs and vesicular transport in ECs and are involved in multiple mechanisms (133, 134)

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These challenges have led to increased interest in innovative therapeutic approaches, such as MSC-Exos, which are naturally biocompatible and possess diverse cytoprotective characteristics (Fig