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Klow-induced changes in skin properties are quantified through established biomarkers that measure collagen structure, elasticity, and tissue behaviour in controlled preclinical models

Current clinical guidelines reflect this evolving evidence

The numbers in Janumet (e.g., 50/500 and 50/1000) refer to the dosage of sitagliptin (in milligrams) and metformin (in milligrams) per tablet

doi: 10.1016/j.cmet.2018.04.010 127

5 Dysesthesia (a skin sensation often described as tingling, numbness, or burning) affected around 21% of people on the 12 mg dose in TRIUMPH-4