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These defects were accompanied by disrupted phosphorylation of the IRS, as well as down-regulated expression of mitochondrial proteins PPAR co-activator 1 (PGC1) and uncoupling protein-2 (UCP-2) [200]

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En los estudios un alto porcentaje de pacientes lograron al menos una prdida del 5% de su peso inicial, especialmente en dosis ms altas de tirzepatida (10 y 15mg)

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These side effects might diminish over time as the body gets used to the medication