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BMC Genomics 9(1):156

The agency has sent warning letters to companies who were found to market fraudulent weight loss injections that contained different ingredients

Compounded semaglutide and vitamin B12 should not be used during pregnancy or breastfeeding, due to potential fetal harm

The co-activation of both receptors in retatrutide may therefore reduce appetite through two partially independent central pathways, which could explain why the compounds appetite-suppressing effects exceed what GLP-1R agonism alone achieves

Adding semaglutide to retatrutide would duplicate GLP-1 receptor activation, which could increase side effects without proportionally increasing efficacy

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