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The GLP-1 receptor limb Through GLP-1R engagement, survodutide is expected to reproduce the familiar incretin effects: glucose-dependent enhancement of insulin secretion, suppression of inappropriate glucagon release in the fed state, delayed gastric emptying, and central appetite suppression that reduces energy intake

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In animal models it repaired cognitive deficits at extraordinarily low doses but no human trials of any kind have been published, and its long-term safety is entirely unknown

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