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The present invention is related to a process for producing semapeptide, the process comprising the steps of, a) culturing a host cell comprising a nucleotide sequence encoding of Formula (II) under suitable conditions for expression, wherein, insoluble tag is a nucleotide sequence of Alanine-Valine

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51 The process as claimed in claim 18, wherein the pH of the buffer solution is about 1 to about 10

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Additionally, we are curious whether adding Lp(a)-lowering therapies on top of statins could further decrease the occurrence of cardiovascular events