Organs such as the kidney, lungs, liver, heart, and even the brain are not left out from this insult, potentially resulting in what is called multiple organ damage (MOD) (Cabrera et al., 2017)
4.1 Central nervous system effects GLP-1R is distributed throughout various regions in the brain, with the highest concentrations being found in the hippocampus and cerebral cortex, areas mainly responsible for cognitive function, memory improvement, and learning ( GLP-1RA plays a key role in promoting CNS health in conditions like T2DM and lowering the risk of stroke ( In the brain, GLP-1RAs perform anti-inflammatory, antioxidant, and anti-apoptotic functions ( Appetite regulation is a common function of many GLP-1RAs, which act on the hypothalamus- the center of hunger and energy balance- and promote feelings of fullness, eventually leading to weight loss ( 4.2 Cardiovascular system effects GLP-1 receptor agonists have a very close connection with cardiovascular outcomes and prevention of many diseases
2,5 As we know, GLP-1 agents cause abdominal pain, constipation, diarrhea, nausea, vomiting, decreased appetite, and dyspepsia that can worsen symptoms of gastroparesis [Table 1]
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Hrvat F, Aleta A, Duho A, Hasani O, Spahi Beirovi L
Anti-aging and antioxidant : Reduces signs of premature aging caused by external aggressors (pollution, UV rays)
