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Combined treatment with high-dose ACEI and sitagliptin significantly increased BP by elevating the expression of substance P, while low-dose ACEI had no such effect ( Renal Mechanisms Underlying the Action of DPP-4i on Hypertension Various factors act upon the renal system and cause water-sodium retention, thus increasing cardiac output and peripheral vascular resistance

This initial phase typically involves receiving infusions once a week for 4 to 6 weeks

References Layton AM, Dreno B, Gollnick HP, Zouboulis CC

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Similar content being viewed by others Introduction Glucagon, a 29 amino acid peptide, was identified a century ago as a hyperglycemic factor derived from the pancreas 1