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Subcutaneous delivery supports controlled systemic exposure and extended receptor engagement in experimental protocols

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Palmitoylation of cysteine residues located at the N-terminus of GAD65 is required for the transport of GAD65 to synaptic terminals [51], and decreased palmitoylation impairs GABAergic neurotransmission, as observed in Huntingtons disease [52]

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2008 doi: 10.1165/rcmb.2007-0371OC