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The use of GLP1s was initially pioneered by bodybuilders in the late 2010s, who discovered that the medication could help with weight loss, and this led to further research and development of the drug for obesity treatment 4m10s

Regarding explanations behind the findings, it is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycemic control in diabetes, there may also be direct neurobiological mechanisms involved for example, through changes in the functioning of the brains reward system, Markku Lhteenvuo , PhD, a study co-author and research director at the University of Eastern Finland, said in the release

If a patient achieves their target weight, a healthcare provider may adjust the dose or recommend a maintenance phase

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