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But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2

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Twelve low-income, predominantly Black neighborhoods in west Louisville face disproportionately high obesity rates (72.7% of Black adults are overweight or obese versus 61.8% white)

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