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[1] Retatrutide: What the Evidence Actually Shows Retatrutides pivotal obesity dataset is a Phase 2, double-blind, randomised, placebo-controlled trial in adults with obesity (or overweight plus a weight-related condition), testing once-weekly doses up to 12 mg over 48 weeks

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Unadjusted and multivariate adjusted weighted Cox proportional risk regressions were used to assess the association between MMA, B12-related biomarkers (serum level, dietary intakes, supplements use, and sensitivity to B12), and the risk of mortality

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However, patient experience is mixed: while some members report no difference between the two methods, others find they do not achieve the same symptom resolution with SC injections