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Importantly, P4-induced slowing of hypothalamic GnRH pulse frequency during the luteal phase alters downstream pituitary signaling dynamics, reinforcing the cyclical alternation between estrogen-dominant and P4-dominant endocrine states [26]
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7b) for both DU-145 and 22Rv1 xenografted mice
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Natural GLP-1 is extremely unstable, with a half-life of only a few minutes, which is why long-acting synthetic agonists were developed for research.
doi: 10.1007/s001250051622 119 SarkarSALeeCEVictorinoFNguyenTTWaltersJABurrackAet al
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