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MHRA Updated Semaglutide Guidance Including NAION Warning (GOV.UK, February 2026) 4

Contact your GP if you experience severe or persistent vomiting lasting more than 24 hours, severe abdominal pain (especially if radiating to the back), signs of dehydration, persistent diarrhoea, or symptoms of hypoglycaemia

The majority of respondents were from the US, with a smaller number from the UK and Sweden

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The key is to favor fat loss over muscle loss

Wegovy works for most people but if you feel hungry all the time and this does not improve, it may be that Wegovy is not the right treatment for you