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In addition, the combination of the two drugs was accompanied by strong AMPK activation, but the pathway was not conclusive

Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study)

doi: 10.1016/j.ecoenv.2022.113550 128 ZhouNLongHYuLXiaXZhuZLiuX

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