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demonstrated that improving mitochondrial metabolism, reducing oxidative stress and mitochondrial fission via the deletion of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), thus alleviating sepsis-mediated myocardial injury, liver injury, and kidney injury in a sepsis model

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This regulatory relationship, termed the metabolic-immune axis, is a crucial factor in the development of immune escape mechanisms by tumors

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Cyclic [G(2,5)pA(3,5)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase

PLoS ONE 2018, human dorsal-root-ganglion neurons: GLP-1R agonists do not excite nociceptors directly and have no effect on capsaicin/TRPV1 responses but enhance ATP/P2X signaling, so TRPV1 is excluded as the channel