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That is a 38% greater reduction

So it was a kind of off-target observation when it was used for individuals with diabetes to then start studying it for obesity

The TRF1 TRFH structure was solved by molecular replacement in Phaser MR 55 within CCP4 56 using the previously published TRF1 TRFH structure as a search model (PDB: 1H6O) 31 , after having first stripped the search model of solvent molecules and ligands

Martn Gimnez VM, de Las HN, Lahera V, Tresguerres JAF, Reiter RJ, Manucha W (2022) Melatonin as an anti-aging therapy for age-related cardiovascular and neurodegenerative diseases