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Further analysis of signaling pathways confirmed that PD effectively upregulated endogenous TGF-/Nodal signaling and downstream Smad2/3 transduction, while concurrently downregulating BMP signaling, leading to robust DE formation

Funding Statement The authors declare that no financial support was received for the research and/or publication of this article

The treatment group exhibited faster re-epithelialization and reduced scarring compared to controls, demonstrating GHK-Cus value in post-procedure formulations (Abdulghani et al., 1998)