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17 Because retatrutide is not yet commercially available in the United States as of July 2025, any switch today would occur in the context of a clinical trial or compassionate-use pathway

Zepbound (tirzepatide) has produced the greatest weight-loss results in clinical trials, followed by Wegovy (semaglutide)

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This includes older adults with age-related declines in growth factors and bone density, smokers (though quitting is more impactful than any supplement), diabetic patients whose healing capacity is compromised by metabolic dysfunction, and those with nutritional deficiencies

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