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TLR4 recognizes lipopolysaccharides (LPS) from Gram-negative bacteria and contributes to hepatocellular injury, insulin resistance, and NASH development

Sato D, Morino K, Ohashi N, et al

This means that we know its long term benefits and side effects

Therefore, side effects like increased heart rate, blood pressure changes, or gastrointestinal issues can occur regardless of timing

Work with a healthcare provider to time the switch appropriately

In addition, PGN has been shown to be absorbed through the GI wall, reaching cells in the liver and being excreted in the urine of animals after prolonged administration