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Neuroinflammation in migraine Neuroinflammation refers to an inflammatory reaction within the CNS, regulated by cytokines, chemokines, reactive oxygen species (ROS), and secondary messengers such as nitric oxide (NO) and prostaglandins (37)

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In relation to the paternal origins of disease, it is significant that endogenous ROS generated by human spermatozoa can, and does, affect sperm function and DNA integrity [6]

Side effects are rare but may include mild redness, swelling, or soreness at the injection site

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