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We excluded clinical studies with the following features: (a) Studies that were non-randomized

The underlying pathogenesis seems to be related to an inflammatory response to foreign microcapsules due to a potential deficiency of enzymes needed to break down the poly-(d,l-lactide- co -glycolide) material into lactic and glycolic acid [58,59,60]

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p = 0.0575), while the slopes were virtually the same in treated with 3 g/day and their matched controls

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