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Excluded were those mothers who anticipated moving out of the area before study completion, who had twin or multiple pregnancies, who were treated for infertility, who tested positive for hepatitis B (hepatitis B surface antigen), HIV, or syphilis (Venereal Disease Research Laboratory test) infections, or who were taking daily vitamin supplements in addition to folic acid and iron

240 Uric acid has been observed to adversely affect -cells, resulting in impaired insulin secretion and decreased functional -cell mass