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[DOI] [PubMed] [Google Scholar] 5.Caputo T, Gilardi F, Desvergne B

They work by: reducing appetite increasing feelings of fullness improving blood sugar regulation Because theyre FDA-approved, clinicians have a much clearer understanding of appropriate dosing, common side effects, and long-term safety compared to investigational drugs like retatrutide

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Extended protocols may run 30-60 days with reduced daily dosing, while intensive short-term approaches might concentrate higher doses over 5-10 days