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MS (ESI, [M+2H] 2+ ) predicted 1327.06, Found 1327.73 MS (ESI, [M+2H] 2+ ) Predicted 1313.05, Found 1313.37
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In primary care, pitfalls include treating presumed infection with antibiotics, or assuming a lesion is a wart, skin tag or patch of eczema and prescribing topical steroids
Side effects are usually mild and dose-dependent
Hruby and Mac Hadley (University of Arizona, USA) in 19871989 Original development program Competitive Technologies Palatin Technologies , later spun off into PT-141 (bremelanotide) Target: non-selective agonist of MC1R, MC3R, MC4R, MC5R (more potent than -MSH, longer half-life) Standard experimental dose in human tanning studies: 0.025 mg/kg subcutaneously (Dorr 1996) In Dorr 1996 (n=10): increase in skin melanin density measured by colorimetry by ~25 % after a 10-day course Main adverse effects in the preclinical literature: nausea, flushing, hyperpigmentation (including atypical nevi), priapism Approximately 100+ publications in PubMed
PMID: 15363636 Hulse JD, et al
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