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Research has shown that their combined stimulation may lead to a more pronounced pulsatile GH release compared to using either pathway alone

Most of these trials measured endpoints like the status of antioxidant enzymes including GPx and inflammatory cytokines in the serum, reduction of radiotherapy side effects (like mucositis, myelosuppression, and diarrhea), and overall improvement of the quality of life

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"Anti-apoptotic and cell survival effects of IGF-I and IGF-II in muscle cells." Apoptosis, 6(1-2), 73-82