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The Dhurat 2013 study included NW IIIIV patients and saw strong results

Through establishing an interleukin (IL)-1-stimulated chondrocytes, it was found that L-theanine could inhibit the nuclear factor kappa B (NF-B) pathway, thereby reducing the expression of proinflammatory factors, including cyclooxygenase-2 (COX-2), prostaglandin E2, inducible nitric oxide synthase, as well as NO, and protect the degradation of extracellular matrix (30)

Handling: Always maintain aseptic laboratory techniques during handling

The impact of inflammatory and metabolic markers on depression, anxiety, and cognition after COVID-19: a narrative review

doi: 10.1007/s10654-021-00754-4