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The expression of GCH1 induces lipid remodeling in cells, inhibiting ferroptosis by selectively preventing the consumption of PLs with two PUFA tails [25]

Figure 3 Supplementation with carnitine may have a positive effect on the -oxidation of fatty acids in mitochondria, thereby promoting lipid metabolism by boosting the uptake of fatty acids and eventually reducing fat accumulation in hepatocytes

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Inoki K, Zhu T, Guan KL

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Recent Phase 3 clinical trials have demonstrated exceptional results, with the REDEFINE program showing weight loss outcomes of up to 20.4% when combined with semaglutide, representing some of the most significant weight reduction results ever achieved in obesity research