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Severe hypoglycemia caused 4 hospital-grade seizures or loss-of-consciousness events out of 71 patients in the Increlex program it is not a theoretical risk

The better option depends on your treatment goal, comfort level, safety needs, and provider recommendation

Zhang Y, Lin Y, Zhang J, Li L, Liu X, Wang T, et al

meaning if you are functionally deficient in B2, it is highly likely you will also have a B12 functional deficiency

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Questions remaining include optimal human dosing, long-term safety, effects across different populations, interactions with diet and exercise, and whether benefits extend beyond weight loss to improvements in cardiometabolic disease outcomes