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Annual Review of Physiology , 73 , 413435

The addition of GIP seems to: Improve insulin sensitivity Reduce compensatory metabolic slowdown Enhance fat loss , particularly subcutaneous fat Retatrutide Retatrutide is a triple agonist (GLP-1, GIP, and glucagon) currently under investigation

These changes enhance its stability and result in a significantly prolonged half-life of 20-30 hours, compared to the much shorter duration of other IGF-1 versions

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FoodData Central. (2019)

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