Cells 12 , 1207 (2023)
This research revealed great potential of bioreducible carboxymethyl dextran nanoparticles for the applications of targeted tumor therapy
69 Potential mechanisms include decreased intestinal lipid production, reduced intestinal triglyceride absorption due to lowered secretion of apoB48-containing chylomicrons, smaller postprandial triglyceride secretion and effects on the expression of genes involved in lipid metabolism
As the master antioxidant, glutathione recycles other antioxidants in the body such as alpha lipoic acid, vitamin C and vitamin E and they rely on glutathione to operate
The primers used for RTPCR were ordered from Integrated DNA Technologies (Coralville, Iowa, USA) and the primer sequences are as follows: Human & mouse ER: sense 5-CCTGGACAAGATCACAG-3 antisense 5-AGCAGGTCATAGAGGGG-3, Human & mouse GPR30: sense 5-CCTGTACTTCATCAACCTG-3 antisense 5-TCATCCAGGTGAGGAAG-3, Human & mouse GAPDH: sense 5-ACTTTGTCAAGCTCATTTCC-3 antisense 5-TCTTACTCCTTGGAGGCCAT-3, Mouse Nrf2: sense 5-CAAGACTTGGGCCACTTAAAAGAC-3 antisense 5-AGTAAGGCTTTCCATCCTCATCAC-3, Mouse NQO1: sense 5-AGCTGGAAGCTGCAGACCTG-3 antisense 5-CCTTTCAGAATGGCTGGCA-3, Mouse HMOX1: sense 5-GCTAGCCTGGTGCAAGATACTG-3 antisense 5-CACATTGGACAGAGTTCACAGC-3, Mouse ABCC1: sense 5-GCGCTGTCTATCGTAAGGCT-3 antisense 5-AGAGGGGCTGACCAGATCAT-3, Mouse ABCG2: sense 5-TGGACTCAAGCACAGCGAAT-3 antisense 5-ATCCGCAGGGTTGTTGTAGG-3, Mouse ABCC3: sense 5-GGGCTCCAAGTTCTGGGAC-3antisense 5-CCGTCTTGAGCCTGGATAAC-3, Mouse CypA: sense 5-CACCGTGTTCTTCGACATCAC -3 antisense 5-CCAGTGCTCAGAGCTCGA AAG -3, Mouse SOD1: sense 5 -CCA GTG CAG GAC CTC ATT TT-3 antisense 5-CAC CTT TGC CCA AGT CAT CT-3, Mouse HPRT: sense 5-GCTGGTGAAAAGGACCTCT-3 antisense 5-CACAGGACTAGAACACCTGC -3
No serious long-term side effects have been reported from regular therapeutic use
