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2 Estrogen is a pleiotropic factor in the hallmarks of aging As a result of modern medicine and prolonged life expectancy, humans can spend more than a third of their lives in the post-reproductive stage, when sex steroid hormone levels markedly decrease (Howdon and Rice, 2018

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doi: 10.3390/jcm10102105 16 EffraimidisG.WiersingaW

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This combination of different methodologies in this study shed light on maternoplacental metabolism and placental endocrine functions as well as steroidogenesis, which allowed us to uncover the association between maternal steroid hormones and placental physiology in healthy pregnancies at term